Health Book Citation

Mechanisms of action and potential outcomes on cellular metabolism curr pharm des. These drugs may be classified according to their mechanism of action as insulinotropic or non insulinotropic.

Antidiabetic Drugs

Authors maria j meneses branca m silva mário sousa rosália s á pedro f oliveira.

Antidiabetic drugs classification and mechanism of action. There are different classes of anti diabetic drugs and their selection depends on the nature of the diabetes age and situation of the person as well as other factors. Biguanides increase insulin action by binding to specific receptors decrease intestinal absorption of carbohydrates and decrease anaerobic gluconeogenesis. They bind avidly to peroxisome proliferator activated receptor gamma in adipocytes to promote adipogenesis and fatty acid uptake in peripheral but not visceral fat.

The thiazolidinediones or glitazones are a new class of drugs for the treatment of type 2 diabetes. They are available as monotherapy or combination therapies with the latter involving two or less commonly three antidiabetic drugs and or. Diabetes mellitus type 1 is a disease caused by the lac.

Thiazolidinediones mechanisms of action. At pancreatic level increase insulin secretion and at the level of pancreatic beta cells they increase the number of insulin receptors. Sulphonylureas are fixing on specific receptors and acts through the potassium channel from the pancreatic and the extra pancreatic level.

Drugs used in diabetes treat diabetes mellitus by altering the glucose level in the blood. With the exceptions of insulin exenatide liraglutide and pramlintide all are administered orally and are thus also called oral hypoglycemic agents or oral antihyperglycemic agents.

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